- Solatorobo: Red the Hunter
- Soldier Front 2
- Soldier of Fortune
- Soldier of Fortune 2: Double Helix
- Soldier of Fortune: Payback
- Soldier vs. Aliens
- Soldiers: Heroes of World War II
- Söldner-X 2: Final Prototype
- SolForge
- Solitairica
- Solium Infernum [I/2009]
- Solium Infernum [II/2023]
- Solo: Islands of the Heart
- SolSeraph
- Solstice Chronicles: MIA
- Solus Project, The
- Soma
- Sombrero: Spaghetti Western Mayhem
- Someday You'll Return
- Somerville
- Son of Nor
- Song in the Smoke
- Song of Horror
- Song of Iron
- Song of Iron 2
- Song of Nunu: A League of Legends Story
- Song of the Deep
- SongArc
- Songs of Conquest
- Sonic & All-Stars Racing Transformed
- Sonic & SEGA All-Stars Racing
- Sonic and the Black Knight
- Sonic at the Olympic Games Tokyo 2020
- Sonic Boom: Fire & Ice
- Sonic Boom: Rise of Lyric
- Sonic Boom: Shattered Crystal
- Sonic CD
- Sonic Colors
- Sonic Dash
- Sonic Dash 2: Sonic Boom
- Sonic Forces
- Sonic Free Riders
- Sonic Generations
- Sonic Jump Fever
- Sonic: Lost World
- Sonic Mania
- Sonic Origins
- Sonic Runners
- Sonic the Hedgehog 2 [II/1992]
- Sonic the Hedgehog 4: Episode 2
- Sonic Unleashed
- Sonny with a Chance
- Sons of Anarchy: The Prospect
- Sons of the Forest
- Sons of Valhalla
- Sorcerer King
- Sorcery Saga: The Curse of the Great Curry God
- SOS [II/2018]
- Soul Axiom
- Soul Captor
- Soul Dance Party
- Soul Hackers 2
- Soul Master
- Soul Reaver 2
- Soul Sacrifice
- Soul Sacrifice Delta
- Soul Saga
- Soul Seeker
- SoulCalibur
- SoulCalibur 2
- SoulCalibur 3
- SoulCalibur 4
- SoulCalibur 5
- SoulCalibur: Broken Destiny
- SoulCalibur Legends
- SoulCalibur: Lost Swords
- SoulCraft 2: League of Angels
- Soulframe
- Soulstice
- Sound Shapes
- Soundfall
- Soup Pot
- Source of Madness
- South of the Circle
- South Park: Phone Destroyer
- South Park: The Fractured But Whole
- South Park: The Fractured But Whole - From Dusk Till Casa Bonita
- South Park: The Stick of Truth
- Sovereignty: Crown of Kings
- Soviet Monsters: Ekranoplans
- Space Age: A Cosmic Adventure
- Space Ark
- Space Bot Alpha
- Space Channel 5 VR: Kinda Funky News Flash!
- Space Chimps
- Space Company Simulator
- Space Crew
- Space Engineers
- Space for Sale
- Space Force: Rogue Universe