- Save the Turtles
- Save Your Mother
- Saving Private Sheep 2
- Saving Yello
- Savior
- Saviors of Sapphire Wings / Stranger of Sword City Revisited
- Saw 2: Flesh and Blood
- Saw: The Video Game
- Say No! More
- Say What You See: Music Edition
- Say What You See: The Collection
- Sayonara Wild Hearts
- Sayri: The Beginning
- SBARG
- SBK 08: Superbike World Championship
- SBK 09: Superbike World Championship
- SBK 2011
- SBK 22
- SBK Generations
- SBK X: Superbike World Championship
- SBK14: Official Mobile Game
- SBK15: Official Mobile Game
- SBX: Invasion
- SCALE
- Scalebound
- Scania: Truck Driving Simulator: The Game
- Scarab Tales
- Scarf
- Scarface: The World Is Yours
- Scarlet Blade
- Scarlet Hood and the Wicked Wood
- Scarlet Legacy
- Scarlet Nexus
- Scars Above
- Scarygirl
- Scathe
- Scavengers
- Scene Investigators
- Scene It? Twilight
- Schacht
- SCHAR: Blue Shield Alliance
- Schein
- Щелкунчик и Крысиный король
- Schizm: Mysterious Journey
- Schizoid
- School 26
- School Bus Fun
- School Girl/Zombie Hunter
- Schoolmates: The Mystery of the Magical Bracelet
- Schools of Magic
- Schrödinger's Cat and the Raiders of the Lost Quark
- Sci-Fantasy Defence
- Sci-Fi Heroes
- SciAnts
- SciBeaver
- Science Girls!
- Scintillatron 4096
- Scivelation
- Scooby Doo! & Looney Tunes Cartoon Universe: Adventure
- Scooby-Doo! and the Spooky Swamp
- Scooby-Doo! First Frights
- Score International Baja 1000
- Scoregasm
- Scorn
- Scorpion Disfigured
- Scotland Yard (2012)
- Scott in Space
- Scott Pilgrim vs. the World: The Game
- Scourge of War: Antietam
- Scourge of War: Brandy Station
- Scourge of War: Chancellorsville
- Scourge of War: Gettysburg
- Scourge of War: Gettysburg 150th Anniversary Collection
- Scourge of War: Pipe Creek
- Scourge of War: Quatre Bras
- Scourge of War: Waterloo
- Scourge: Outbreak
- Scourge Project: Episodes 1 and 2, The
- ScourgeBringer
- SCP-479: Shadows of the Mind
- SCP Operations
- SCP: Secret Files
- Scrabble Interactive: 2009 Edition
- Scram Kitty and His Buddy on Rails
- Scrap Games
- Scrap Mechanic
- Scrap Metal
- Scrap Squad
- Scrapbook Paige
- Scrapland
- Scrapland Remastered
- Scrapnaut
- Scraps: Modular Vehicle Combat
- Scratches
- Scratches: Director's Cut
- ScreamRide
- Screencheat
- ScrewUp
- Scribble Defense
- Scribble Space