- Secret Ponchos
- Secret Saturdays: Beasts of the 5th Sun, The
- Secret Service
- Secret World, The
- Secrets of Grindea
- Secrets of Rætikon
- Secrets of the Titanic 1912-2012
- Secrets of the Vatican: The Holy Lance
- Section 8
- Section 8: Prejudice
- Sector 13
- Sector 7-4-9er
- Seduce Me the Otome
- Seed of Life
- Seed of the Dead: Sweet Home
- Seekers: Survival, The
- Seep Universe
- Sega Genesis Classic Collection: Gold Edition
- SEGA Mega Drive Classic Collection Volume 1
- SEGA Mega Drive Classic Collection Volume 2
- SEGA Mega Drive Classic Collection Volume 3
- SEGA Mega Drive Classic Collection Volume 4
- SEGA Rally Online Arcade
- Sega Superstars Tennis
- Сегодня, мама!
- Sekiro: Shadows Die Twice
- Selaco
- Self-Defense Training Camp
- Self-Isolation
- Selfloss
- Selknam Defense
- Semblance
- Semispheres
- Sengoku Basara 4
- Sengoku Basara: Samurai Heroes
- Sengoku Dynasty
- Sengoku [II/2011]
- Sengoku Jidai: Shadow of the Shogun
- Senran Kagura 2: Deep Crimson
- Senran Kagura: Bon Appétit!
- Senran Kagura Burst
- Senran Kagura Burst: Crimson Girls
- Senran Kagura Burst Re: Newal
- Senran Kagura: Estival Versus
- Senran Kagura: Peach Ball
- Senran Kagura: Peach Beach Splash
- Senran Kagura Reflexions
- Senran Kagura: Shinovi Versus
- Senran Kagura: Skirting Shadows
- Sensational World Soccer 2010
- Sense – 不祥的预感: A Cyberpunk Ghost Story
- Sensei Wars
- Sententia
- Sentinel
- Sentinel 3: Homeworld
- Sentinel 4: Dark Star
- Sentinel Command
- Sentinel: Cursed Knight
- Sentinel Heroes
- Sentinels of the Multiverse: The Video Game
- Sentry
- Senua's Saga: Hellblade 2
- September 7th
- Sequence
- Seraph
- Serena
- Serf City: Life Is Feudal
- Serial Cleaner
- Serial Cleaners
- Serin Fate
- Serious Sam
- Serious Sam 2
- Serious Sam 3: BFE
- Serious Sam 3: Jewel of the Nile
- Serious Sam 4
- Serious Sam Classics: Revolution
- Serious Sam Collection, The
- Serious Sam Double D
- Serious Sam HD: The First Encounter
- Serious Sam HD: The Second Encounter
- Serious Sam: Kamikaze Attack!
- Serious Sam: Next Encounter
- Serious Sam: Siberian Mayhem
- Serious Sam: The First Encounter
- Serious Sam: The Random Encounter
- Serious Sam: The Second Encounter
- Serious Sam: Tormental
- Serious Sam VR: The Last Hope
- Serious Sam's Bogus Detour
- Serpent in the Staglands
- Serpent of Isis, The
- Serpent Rogue, The
- Serum
- Servo
- Sesame Street: Cookie's Counting Carnival
- Sesame Street: Elmo's A-to-Zoo Adventure
- Sesame Street: Elmo's Musical Monsterpiece
- Sesame Street: Once Upon a Monster
- Sesame Street: Ready, Set, Grover!
- Session: Skate Sim