- Shadow Empire
- Sexy Beach Premium Resort
- Sevencore
- Seven Souls Online
- Seven Kingdoms: Conquest
- Settlers: Rise of an Empire, The
- Settlers: Kingdoms of Anteria, The
- Settlers: Heritage of Kings, The
- Settlers: Fourth Edition, The
- Settlers 4 Mission Pack, The
- Settlement: Colossus
- Serum
- Serious Sam's Bogus Detour
- Serious Sam VR: The Last Hope
- Serious Sam: The Random Encounter
- Sentry
- Sengoku [II/2011]
- Sengoku Dynasty
- Sega Genesis Classic Collection: Gold Edition
- Secret of the Solstice
- Secret Files 3
- Secret Agent HD
- Second Guest, The
- Search for Amelia Earhart, The
- Seal of Evil
- Sea Legends
- SCUM
- Scraps: Modular Vehicle Combat
- Scourge of War: Gettysburg
- Scorpion Disfigured
- Schein
- Scarlet Legacy
- Scarlet Blade
- Saurian
- Satisfactory
- Sands of Aura
- Samudai
- Samantha Swift and the Hidden Roses of Athena
- Sam & Max: Episode 205 - What's New, Beelzebub?
- Sam & Max: Episode 203 - Night of the Raving Dead
- Sam & Max: Episode 202 - Moai Better Blues
- Salem
- Saira
- Sail Simulator 2010
- SAGA Online
- Saga
- Sacred Tears True, The
- Sacraboar
- S4 League
- S.T.A.L.K.E.R.: Shadow of Chernobyl
- S.T.A.L.K.E.R.: Clear Sky
- S.T.A.L.K.E.R.: Call of Pripyat
- Rusty Hearts
- Russian Fishing 4
- Runes of Magic
- Rune 2
- Run and Fire
- Rumble Fighter
- Royal Quest
- Royal Envoy
- Rotwood
- room13
- Rooks Keep
- Romero's Aftermath
- ROM: Extraction
- Rollers of the Realm: Reunion
- RollerCoaster Tycoon World
- Rogue Command
- Robin Hood: Sherwood Builders
- Rivals of Aether 2
- Rite of Ilk
- Rising Storm 2: Vietnam
- Rising Islands
- Rise of Venice
- Rise of the Triad
- Rise of Prussia
- Rise of Nations: Rise of Legends
- Rise of Nations
- Rise of Keepers
- Rise of Incarnates
- Riptale
- Ring Runner: Flight of the Sages
- Ring of Elysium
- Rig'n'Roll
- Rift: Storm Legion
- Rift Loopers
- Rift
- Ridge
- Richard & Alice
- Rhiannon: Curse of the Four Branches
- rFactor 2
- Revival: Recolonization
- Revival
- Revenant Prince, The
- Revelation Online
- Reus
- Return of the Phantom
- Retrovirus
- Restaurant Empire 2
- Resonance [II/2012]