- Shadowrun Trilogy
- Shadows: Awakening
- Shadows of Kurgansk
- Shady Part of Me
- Shakes on a Plane
- Shame Legacy
- Shantae and the Pirate's Curse
- Shantae and the Seven Sirens
- Shantae: Half-Genie Hero
- Shantae: Risky's Revenge
- Shape of the World
- Shape Up
- Shapeshifting Detective, The
- Shaq Fu: A Legend Reborn
- Shatter Remastered Deluxe
- Shattered: Tale of the Forgotten King
- She Dreams Elsewhere
- Sheltered
- Shenmue 1 & 2
- Sherlock Holmes: Chapter One
- Sherlock Holmes: Chapter One - Beyond a Joke
- Sherlock Holmes: Crimes and Punishments
- Sherlock Holmes: The Awakened [II/2023]
- Sherlock Holmes: The Devil's Daughter
- Shift Happens
- Shift Quantum
- Shiftlings
- Shikhondo: Soul Eater
- Shin Megami Tensei 5
- Shin Megami Tensei: Persona 3
- Shin Megami Tensei: Persona 4
- Shiness: The Lightning Kingdom
- Shing!
- Shining Resonance
- Shiny
- Ship Graveyard Simulator
- Short Hike, A
- Shoulders of Giants
- Shovel Knight
- Shovel Knight: Dig
- Shovel Knight: Specter of Torment
- Sid Meier's Civilization 6
- Sid Meier's Civilization 6: Babylon Pack
- Sid Meier's Civilization 6: Byzantium & Gaul Pack
- Sid Meier's Civilization 6: Ethiopia Pack
- Sid Meier's Civilization 6: Gathering Storm
- Sid Meier's Civilization 6: Maya & Gran Colombia Pack
- Sid Meier's Civilization 6: Portugal Pack
- Sid Meier's Civilization 6: Rise and Fall
- Sid Meier's Civilization 6: Vietnam and Kublai Khan Pack
- Siegecraft Commander
- Sifu
- Signalis
- Signifier, The
- Silence
- Simon the Sorcerer: Origins
- Sims 4, The
- Sims 4: Cottage Living, The
- Sims 4: Discover University, The
- Sims 4: Dream Home Decorator, The
- Sims 4: Eco Lifestyle, The
- Sims 4: Island Living, The
- Sims 4: My Wedding Stories, The
- Sims 4: Paranormal Stuff, The
- Sims 4: Snowy Escape, The
- Sims 4: Star Wars - Journey to Batuu, The
- Simulacra
- Sin Slayers
- Sine Mora EX
- Sinking City, The
- Sinner: Sacrifice for Redemption
- Sisters 2: Road to Fame, The
- Skara: The Blade Remains
- Skate City
- Skatebird
- Skater XL
- Skelattack
- Skeletal Avenger
- Sker Ritual
- Skinny & Franko: Fists of Violence
- Skul: The Hero Slayer
- Skull Island: Rise of Kong
- Skullgirls
- Skully
- Sky Beneath
- Sky Force Anniversary
- Sky Force Reloaded
- Skydrift Infinity
- Skyforge
- Skyhill
- Skylanders Imaginators
- Skylanders: SuperChargers
- Skylanders: SWAP Force
- Skylanders Trap Team
- Skylar & Plux: Adventure on Clover Island
- Skylia Prophecy, The
- Slain: Back from Hell
- SlashDash
- Slave Zero X
- Slayaway Camp