- Omerta: City of Gangsters - Damsel in Distress
- Omerta: City of Gangsters - The Arms Industry
- Omerta: City of Gangsters - The Bulgarian Colossus
- Omerta: City of Gangsters - The Con Artist
- Omerta: City of Gangsters - The Japanese Incentive
- OMG-Z
- Omikron: The Nomad Soul
- Omnibion War
- OmniBus
- Omno
- OMON Simulator
- OMSI 2
- OMSI: The Bus Simulator
- On a Roll 3D
- On Rusty Trails
- On the Front Line
- On the Road: Truck Simulator
- Once a Tale
- Once Bitten, Twice Dead!
- Once Upon a Time in Roswell
- Onde
- One Day for Ched
- One Day in London
- One Day More
- One Eleven
- One Finger Death Punch
- One Finger Death Punch 2
- One Hand Clapping
- One Hundred Ways
- One Last Breath
- One Last Dinner
- One Last Memory
- One Late Night: Deadline
- One Line Coloring
- One Lonely Outpost
- One Military Camp
- One More Dungeon
- One More Dungeon 2
- One More Gate: A Wakfu Legend
- One Piece: Burning Blood
- One Piece Odyssey
- One Piece: Pirate Warriors 3
- One Piece: Pirate Warriors 4
- One Piece: Unlimited World Red
- One Piece: World Seeker
- One Punch Man: A Hero Nobody Knows
- One Shell Straight to Hell
- One Ship, Two Ship, Redshift Blueshift
- One Sole Purpose
- One Step from Eden
- One True Hero
- One Way Heroics
- One Way to Die
- Onechanbara Z2: Chaos
- Onee Chanbara Origin
- Ong-Bak Tri: The Video Game
- Ongaku
- Onigiri
- Oniken
- Onikira: Demon Killer
- Onimusha: Warlords
- Oninaki
- Oniria Crimes
- Onirike
- Onironauta
- Online Soccer Champions
- OnlineWorms
- Only After
- Only One
- Only Up!
- Onmyoji
- Ontotis
- Onward
- Ooblets
- Oozi: Earth Adventure - Episode 1
- Oozi: Earth Adventure - Episode 3
- Oozi: Earth Adventure - Episode 4
- Open Country
- Open Fire Gold
- Open Roads
- Open Sea Fishing: The Simulation
- Opera Slinger
- Операция "Багратион"
- Operation Abyss: New Tokyo Legacy
- Operation Babel: New Tokyo Legacy
- Operation Barbarossa: The Struggle for Russia
- Operation: Black Mesa
- Operation Body Count
- Operation Breakout
- Operation Flashpoint: Dragon Rising
- Operation Flashpoint: Red River
- Operation: Harsh Doorstop
- Operation: Matriarchy
- Operation Stormfront
- Operation: Tango
- Operation Thunderstorm
- Operation Wolf Returns: First Mission
- Operation Wolfsburg
- Operencia: The Stolen Sun
- Oppcium