- Star Realms
- Star Ocean: The Last Hope
- Star Conflict
- Stalin vs. Martians
- Square Planet
- Sports Car Challenge
- Splot
- Splatters, The
- Splatter
- Spitlings
- Spirits
- Spiral Knights
- Spider-Man: Shattered Dimensions
- Special Forces: Team X
- Spaceland
- Spacebase Startopia
- Space Rogue
- Space Rangers: Legacy
- Space Pirates and Zombies 2
- SoulCraft 2: League of Angels
- SoulCalibur 3
- Sonic Chronicles: The Dark Brotherhood
- Sonic & SEGA All-Stars Racing
- Sonic & All-Stars Racing Transformed
- SolForge
- Solasta: Crown of the Magister
- SolaRola
- Solarix
- Solar Swarm
- Solar Flux
- Söldner: Secret Wars
- Slender: The Arrival
- Slam Dunk Basketball 2
- Skyward Collapse
- Skyforge
- Skyborn
- Sins of a Dark Age
- SiN: Reloaded
- Sims 2, The
- SimCity Deluxe
- Sifu
- Sid Meier's Civilization: Beyond Earth - Rising Tide
- Sid Meier's Civilization 4
- Sid Meier's Alpha Centauri
- Sid Meier's Ace Patrol: Pacific Skies
- Shovel Knight
- Shoot the Zombirds
- Ship: Remasted, The
- Shiness: The Lightning Kingdom
- Shin Megami Tensei: Devil Survivor - Overclocked
- Shin Megami Tensei: Devil Survivor
- Sherlock Holmes: The Awakened Remastered Edition
- Sherlock Holmes: Chapter One
- She Dreams Elsewhere
- Shattered Planet
- Shank
- Shallow Space
- Shadowrun: Hong Kong
- Shadowrun: Dragonfall - Director's Cut
- Shadowrun: Dragonfall
- Shadowrun Chronicles: Boston Lockdown
- Shadow of the Game
- Shadow of the Beast [II/2016]
- Sevencore
- SEUM: Speedrunners from Hell
- Settlers: Fourth Edition, The
- Servo
- Serpent in the Staglands
- Serious Sam: Siberian Mayhem
- Seraph
- Senran Kagura: Skirting Shadows
- Senran Kagura Burst: Crimson Girls
- Section 8
- Second Chance Heroes
- Sea Stars
- Scrolls
- Scrapland
- Scourge: Outbreak
- Scourge of War: Gettysburg
- Scivelation
- Scavengers
- Scarface: The World Is Yours
- Say What You See: Music Edition
- Save the Turtles
- Satellite Reign
- Saints Row: The Third
- Saints Row 2
- Sacred 2: Fallen Angel
- S.T.A.L.K.E.R.: Shadow of Chernobyl
- S.T.A.L.K.E.R. 2: Heart of Chornobyl
- RVL Hacker
- Rush for Glory
- Runes of Magic
- Rune Factory: Frontier
- Run Like Hell!
- Run and Fire
- Room, The
- Rock of Ages
- Rock Band 4
- Rock Band 2