- Reel Fishing Paradise 3D
- Regular Show: Mordecai and Rigby in 8-Bit Land
- Resident Evil: Revelations
- Resident Evil: The Mercenaries 3D
- Retro City Rampage
- Return to PopoloCrois: A Story of Seasons Fairytale
- Rhythm Thief & the Emperor's Treasure
- Ridge Racer 3D
- Riding Star 3D
- Rise of the Guardians: The Video Game
- Rising Board 3D
- River City: Rival Showdown
- Robot Rescue 2
- Robot Rescue 3D
- Rodea the Sky Soldier
- RollerCoaster Tycoon 3D
- Rune Factory 4
- Runny Egg
- Saban's Power Rangers Megaforce
- Saban's Power Rangers Super Megaforce
- Safari Quest
- Samurai G
- Samurai Warriors: Chronicles
- Samurai Warriors: Chronicles 3
- Scooby Doo! & Looney Tunes Cartoon Universe: Adventure
- Scribblenauts Unlimited
- Scribblenauts Unmasked: A DC Comics Adventure
- Secret Journeys: Cities of the World
- Secret Mysteries in London
- Senran Kagura 2: Deep Crimson
- Senran Kagura Burst
- Senran Kagura Burst: Crimson Girls
- Senran Kagura: Skirting Shadows
- Severed
- Shakedown: Hawaii
- Shanghai Mahjong
- Shantae
- Shantae and the Pirate's Curse
- Sherlock Holmes and the Mystery of the Frozen City
- Shifting World
- Shin Megami Tensei 4
- Shin Megami Tensei 4: Apocalypse
- Shin Megami Tensei: Devil Summoner - Soul Hackers
- Shin Megami Tensei: Devil Survivor 2 - Record Breaker
- Shin Megami Tensei: Devil Survivor - Overclocked
- Shin Megami Tensei: Strange Journey Redux
- Shinobi [III/2011]
- Shovel Knight
- Shovel Knight: Specter of Torment
- Siesta Fiesta
- Sims 3, The
- Sims 3: Pets, The
- Skylanders: Giants
- Skylanders: Spyro's Adventure
- Skylanders: SuperChargers
- Skylanders: SWAP Force
- Skylanders Trap Team
- SkyPeace
- Slime MoriMori Dragon Quest 3: The Great Pirate Ship and Tails Troupe
- Slitherlink by Nikoli
- Smurfs 2, The
- Smurfs, The [IV/2015]
- Snakenoid Deluxe
- Snow Moto Racing 3D
- Soccer Up!
- Sonic & All-Stars Racing Transformed
- Sonic Boom: Fire & Ice
- Sonic Boom: Shattered Crystal
- Sonic Generations
- Sonic: Lost World
- Sonic the Hedgehog 2 [I/1992]
- Sonic the Hedgehog 2 [II/1992]
- SpeedX 3D
- Spelunker
- Spider-Man: Edge of Time
- Spirit Camera: The Cursed Memoir
- SpongeBob HeroPants
- SpongeBob SquarePants: Plankton's Robotic Revenge
- SpongeBob SquigglePants
- Spot the Differences!
- Spy Hunter [II/2012]
- Squids Odyssey
- Star Fox 64 3D
- Star Wars Pinball
- SteamWorld Dig
- SteamWorld Dig 2
- SteamWorld Heist
- Steel Diver
- Steel Diver: Sub Wars
- Steel Empire [II/2014]
- Stella Glow
- Story of Seasons
- Streets of Rage 2
- Style Savvy: Styling Star
- Style Savvy: Trendsetters
- Sudoku by Nikoli
- Sudoku: The Puzzle Game Collection
- Sumico
- Super Black Bass 3D
- Super Mario 3D Land